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While, α-synuclein seeds have already been found in various tissues and blood of individuals with synucleinopathies, its potential for a biomarker is ambiguous.
They noticed the synuclein seed framework different with the type of synucleinopathy. PD and DLB seeds showed paired filaments whereas MSA seeds had two unique constructions – twisted and straight filaments. This finding was confirmed that IP/RT-QuIC coupled with TEM can differentiate among synucleinopathies determined by disorder distinct seed framework.
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